With very few exceptions, these persons report intolerance to SSRI antidepressants and antihistamines. A high percentage are non-competitive persons who complain of chemical and food sensitivities… – shootings at Columbine High School and Virginia Tech were carried out by students taking SSRIs.1
~ William Walsh
Typical features of overmethylation include excellent socialization skills, many friendships, non-competitiveness, artistic or musical interests, chemical and food sensitivities, and a tendency for high anxiety.
~ William Walsh
WD2: Walsh Depression #2 – This is the second in a series [WD1: Undermethylation here] of 5 posts on Dr Bill Walsh's 5 biotypes of depression as described in his book Nutrient Power 2 and listed below. This particular biotype is most important to CorePsych readers because of the 5 subtypes this type of depression also correlates in his data three times more frequently with ADHD and more academic underachievement than the first Undermethylated biotype.
This brief video on this second WD2 – Walsh depression biotype [2 of 5] – will remind you of the fact that depression is more than just an appearance of sadness. Overmethylated depression will prove untreatable if not measured and addressed with some of the laboratory inquiries linked below. Too many fail SSRI treatments with trial after trial of otherwise appropriate medications for the symptoms, not the biologically-based disorder.
From appearances to measurable science – biotype laboratory neurophysiological assessments will change treatment outcomes for depression and a variety of other mind-presentations. Markers matter. Even small markers matter in a sea of navigational guesswork and treatment failure.
Dr Walsh has presented his research at the American Psychiatric Association, the U.S. Senate, the National Institute of Mental Health, the Society for Neuroscience, and has been a speaker at more than 30 international conferences. He has authored more than 200 scientific articles and reports, and has five patents.
Dr Walsh has researched biomedical details for individuals previously considered as untreatable: from personality disorders to others insufficiently treatable with modern psychopharmacology. He's published research and biomedical evaluations on lost souls from murderers to those more commonplace presentations of untreatable depression and ADHD. Think: new options for treatment failure at any level of mind alteration.
If you're interested in learning more about his groundbreaking work consider attending his Walsh Research Institute meeting in Chicago Oct. 18-22, next month.
Back to WD2 refractory depression: This video and then a brief discussion of overmethylation: 4, 5
These replicable medical findings clearly encourage more complete assessments – Summarized from Nutrient Power 3 Walsh's most recent book. In Nutrient Power Dr Walsh details of how to both measure and treat this specific, easily identified form of depression.
*Don't let the nutritional title trivialize your response.* Read this book. Measure for methylation imbalances via whole blood histamine.
Important indicators of this overmethylation, low folate depression syndrome include a whole blood histamine level below 40 ng/ml and an elevated SAMe/SAH ratio 7 in combination with key symptoms and traits including OCD tendencies, seasonal allergies and a history of perfectionism.
Treat the underlying overmethylation problem as it looks in your life, your offices. We now measure for these methylation issues at CorePsych.
Characteristics of Overmethylation – Incidence: 20% of clinical depression [n – 2800]:
- Improvement after folate therapy
- High anxiety, panic tendency, talkative
- Adverse reaction to SSRIs
- Improvement after benzodiazapines
- Food and chemical sensitivities
- Absence of seasonal allergies
- Dry eyes and mouth
- Low libido
- High artistic abilities and interest
- Hirsutism – excess hair (males only)
- Nervous legs, pacing
- Sleep disorder
- Noncompetitive in sports, games
- Underachievement in school
- Estrogen intolerance [~ estrogen dominance]
- Hyperactivity 6
Do you see anything familiar in treatment refractory individuals you know or treat? Did the words adverse reactions to SSRIs and high anxiety catch your attention? Do you think that low libido, sleep disorder, underachievement in school and Executive Function challenges sound familiar as a symptom complex associated with depression?
Increased anxiety for the first 2-3 weeks, followed by sharp improvement in 4-8 weeks and significant effectiveness in 3-4 months.
Soon: the additional four Walsh depression biotypes, 3 and incidence in his research.
+ 2 Video Playlists on Epigenetics: 1. Public, 2. Professionals, & one program by
Dr Walsh on Epigenetics and Methylation
Register for, and make sure you go back to watch, our Rick Green/Parker Webinars as we discuss Why [Dig Deeper], How [Brain Function] and, in the third TotallyADD Webinar, What [To Explore] series. Topics: psychiatric diagnosis and treatment for ADHD/Executive Function. Mind science is slowly but inexorably changing. Watch the first two meetings to prepare for our anticipated discussion about Dr Walsh's laboratory measurements and nutrient interventions in the third webinar. Details matter.
NB: The first Why Webinar is now recorded and ready for review. Prepare for How coming on Oct. 19, available here:
Do subscribe below for future CorePsych updates, and please forward these important new data-tools to your colleagues.
Dr Charles Parker
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Complimentary & New: 23 pg Special Report: Predictable Solutions For ADHD Medications
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1 Larkin RW. (2007). Comprehending Columbine. Temple University Press: Philadelphia. Reported by Dr Walsh at the Amer. Psychiatric Assoc meeting in '14
2 Walsh, WJ, Nutrient Power – Heal Your Biochemistry and Heal Your Brain, Skyhorse Publishing 2012.
3 Ibid., p 77.
4 Ibid., p 150.
5 Walsh WJ, Rehman F. (1997). Methylation syndromes in mental illness. Abstracts: Society for Neuroscience 27th Annual Meeting (pt 2). New Orleans, LA, October 25-29.
6 Walsh, Dr. William J. (2014-05-06). Nutrient Power: Heal Your Biochemistry and Heal Your Brain (Kindle Locations 1483-1488). Skyhorse Publishing. Kindle Edition.