IgG Labs Evolve

Gluten Summit Library Michael Marsh
November 12, 2013
ADHD Medication Love
November 19, 2013

IgG Laboratory Evidence Evolves

Gluten, casein, immunity, brain function

Gluten Data | Brain Function

The IgG nay-sayers simply need to look at available new data on precision with IgG testing. The woefully outdated focus on celiac disease [CD – end stage villous atrophy Marsh 3 & 4]  misses the gluten sensitivity point: Undiagnosed gluten and casein sensitivity directly affect brain function.

If anyone misses contributory IgG factors associated with gluten sensitivity you can suffer with mind altering disorders for the rest of your life, and they will remain untreatable. Yes, we can fix the symptoms, but the mind disorder will remain misunderstood, undiagnosed, untreated, and refractory to casual care. Think: cytokine parade.

Beyond Casual Care for ADHD, Depression, Bipolar, Anxiety, Sleep Disorder

You know me, readers – I'm doing everything I can to stay on top of the rapidly evolving biomedical science. Testing matters. What I'm reporting in these brief updates was simply not available just a few years ago. I hate to miss a diagnosis and thereby perpetuate any suffering – and if I don't use the best evidence, the best data, I'm either in denial or awash in group-think.  This is the reason I'm switching to Cyrex Labs for immunity testing – using Array 3 as a baseline for IgG [etc] testing. I'll be posting more on these new data points through the Holiday Season.

These biomedical testing details – including why: reasons for, and how: useful testing data/recommendation maps – remain available in world class order at the Gluten Summit Site for download in audio, pdf and video programs.

IgG | Immunity Details Matter

Brief: from the Array 3 Protocol Outline:

Negative serology should not necessarily reassure the clinician of neither negative immune activation nor pathology. Several reports show that in the majority of celiac patients antibodies to gliadin and transglutatminase may be negative.1, 2, 3 [see Refs below]

The Point Is…

That if one doesn't measure the specific antigenic activity the real diagnosis remains missed. Reality remains overlooked. New technology changes the face of psychiatry and the clinical intervention systems for commonplace brain disorders such as ADHD, depression and anxiety.

I'll be meeting with Aristo Vojdani PhD, Chief Scientific Advisor for Cyrex, at ACAM in Palm Springs this week to learn and report more… Stay tuned.


1 Tursi A, Br Med J 2005 http://www.bmj.com/rapid-response/2011/10/30/seronegative-coeliac-disease-clinical-challenge
2 Tursi A, Brandimarte G, Giorgetti G, Gigliobianco A, Lombardi D, Gasbarrini G. Low prevalence of antigliadin and anti-endomysium antibodies in subclinical/silent coeliac disease. Am J Gastroenterol 2001; 96: 1507- 10
3 Tursi A, Brandimarte G, Giorgetti G. Prevalence of anti-tissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. J Clin Gastroenterol 2003; 36: 219-221



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  3. Sloane Kettering says:

    Hello Dr Parker,

    Could I ask how long it takes for the Gut to heal once the main Igg Allergies are removed?

    What I mean is: how long should it take the Psych Meds to work again if you avoid your main allergies?

    Assuming there are no other issues (leaky gut, mineral deficiencies, Adrenal Issues?)



    • Sloane,
      Clinical response varies from ~ 2 weeks to 1 year. It depends on the duration of the chronicity. Literature on review says 6-9 mos on a cellular level. If a person isn’t better on my watch in 2-3 mos I review what I’ve suggested or evaluated, as I’m likely missing something.

  4. Sean Reardon says:

    Hello Dr Parker,

    I wanted some advice on Igg testing. I signed up for an Igg test which allowed you to have 2 Igg tests at 2 different points in time – their justification being that if you avoid certain foods you can eat them again.
    On my first test I had allergies to the New Jersey Trifecta of Eggs, Milk and Gluten – They happened to be the food I at most frequently (I love scrambled eggs for breakfast).

    I avoided these foods completely; taking great care to ensure that I read food packaging labels.

    6 months later I had another Igg test which came back to say that I did not have allergies to Egg, Milk or Gluten any longer but instead it was Potato, Mushroom, Avocado and Coffee. Again these were the foods I had been eating most frequently.

    I am now feeling very confused about which foods I should be eating? I have always had a 18-24 hour transit time from the mouth to the south and have not noticed any improvements in my therapeutic window.

    What would your recommendations do you have as your knowledge on Psychiatric medications and food sensitivity is 2nd to none?

    Much obliged.


    • Sean,

      My best understanding at this time, based upon the Gluten Summit [ http://bit.ly/1cSYGZ6 ] and years of discussions at meetings before this Summit: 1. the controversy rages based upon these lab findings that do vary
      2. everyone, except those less informed, recommend: stay off the main offenders for life
      3. no need to wax fascistic about every morsel, as I’ve seen remarkable turn arounds just avoiding the macro version of the food in question
      4. labs absolutely do vary – we’re switching to Cyrex for that very point
      5. cross-reactivity occurs quite commonly, and autoimmunity follows, more reportage coming in later posts
      6. some individuals can’t take a morsel of gluten/whatever as they are far more sensitive
      7. the jury, the data, the science continues to evolve – so, as I often point out here, no pat answers
      8. start w a plan, follow it, and, from my own personal experience with hundreds of folks – stay on the track. I jokingly tell folks, rethink the whole thing later and go off the diet, and you’ll have a reason to see me again. It’s good for psych business everywhere! 😉

      Hope this helps,

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  6. Erich says:

    Hi, Dr. Parker- can I assume you would order one of the Cyrex panels for IgG testing? If so, which test would you tend to use, and what’s the retail charge for that test?

    • Erich,
      The best starting point is the Array 3 as it breaks down all of the gluten subsets. If you know you have gluten, but don’t get better on that diet the Array 4 on cross sensitivity is the next one to order. The price for Array 3 is 320$, a bit more than Great Plains, but covers so much more. Available thru Desiree at http://corepsych.com/services. Don’t know the price for Array 4, it’s more complicated, more info, and costs more – Desiree can tell you exact $ – that one isn’t right on top at the moment.

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