If you have any interest in why so much news about gluten sensitivity and immune dysregulation. you will love this news – the details down to the epitope [the part of the antigen that is recognized by the immune system]! You heard it first here! 😉
Take a quick look at the details of how and why immunity issues continue to proliferate in this interesting article over at Celiac.com by Jefferson Adams: Are New Wheat Breeds Driving Up Celiac Disease Rates?
Here are the details:
According to a new study by a team of plant researchers from The Netherlands, it's possible that modern wheat breeding habits have promoted an increase in celiac disease epitopes, and thus a proliferation of celiac disease.
Generally, the modern wheat varieties showed higher levels of Glia-alpha9 epitope, and lower levels of Glia-alpha20 epitope compared to the older varieties. This indicates that modern wheat breeding methods may have promoted an increase in celiac disease epitopes, and thus a proliferation of celiac disease.
The research team set out to compare the presence of celiac disease epitopes in modern and old hexaploid wheat varieties. The team included H. C. van den Broeck, H. C. de Jong, E. M. Salentijn, L. Dekking, D. Bosch, R. J. Hamer, L. J. Gilissen, I. M. van der Meer, and M. J. Smulders, all affiliated with Plant Research International, Wageningen, The Netherlands.
It's well-known that gluten proteins from wheat can induce celiac disease in genetically susceptible individuals. This happens when antigen presenting cells expose gluten-sensitive T-cell lymphocytes to specific gluten peptides.
To analyze whether wheat breeding contributed to the increase of the prevalence of celiac disease, the team compared genetic diversity of gluten proteins for the presence of two celiac disease epitopes (Glia-alpha9 and Glia-alpha20).
They examined samples of 36 modern European wheat varieties and 50 older varieties grown up to the beginning of the 20th century. Glia-alpha9 is a major (immunodominant) epitope that triggers sensitivity in most celiac disease patients. The minor Glia-alpha20 is included as a technical reference.
Here is the ref for your review:
From Theoretical and Applied Genetics: Theor Appl Genet. 2010 Jul 28. PMID: 20664999
– And just remember this list of: Celiac and Gluten Associated Medical Disorders